![Frontiers | The Off-Targets of Clustered Regularly Interspaced Short Palindromic Repeats Gene Editing Frontiers | The Off-Targets of Clustered Regularly Interspaced Short Palindromic Repeats Gene Editing](https://www.frontiersin.org/files/Articles/718466/fcell-09-718466-HTML/image_m/fcell-09-718466-g001.jpg)
Frontiers | The Off-Targets of Clustered Regularly Interspaced Short Palindromic Repeats Gene Editing
![Towards application of CRISPR-Cas12a in the design of modern viral DNA detection tools (Review) | Journal of Nanobiotechnology | Full Text Towards application of CRISPR-Cas12a in the design of modern viral DNA detection tools (Review) | Journal of Nanobiotechnology | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs12951-022-01246-7/MediaObjects/12951_2022_1246_Fig1_HTML.png)
Towards application of CRISPR-Cas12a in the design of modern viral DNA detection tools (Review) | Journal of Nanobiotechnology | Full Text
![Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assay | Nature Communications Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assay | Nature Communications](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41467-020-18575-6/MediaObjects/41467_2020_18575_Fig1_HTML.png)
Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assay | Nature Communications
![Functional Insights Revealed by the Kinetic Mechanism of CRISPR/Cas9 | Journal of the American Chemical Society Functional Insights Revealed by the Kinetic Mechanism of CRISPR/Cas9 | Journal of the American Chemical Society](https://pubs.acs.org/cms/10.1021/jacs.7b13047/asset/images/large/ja-2017-13047q_0010.jpeg)
Functional Insights Revealed by the Kinetic Mechanism of CRISPR/Cas9 | Journal of the American Chemical Society
![Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles | Nature Communications Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles | Nature Communications](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41467-021-26989-z/MediaObjects/41467_2021_26989_Fig1_HTML.png)
Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles | Nature Communications
![PDF] Mg2+-dependent conformational rearrangements of CRISPR-Cas12a R-loop complex are mandatory for complete double-stranded DNA cleavage | Semantic Scholar PDF] Mg2+-dependent conformational rearrangements of CRISPR-Cas12a R-loop complex are mandatory for complete double-stranded DNA cleavage | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/39a49b3103ff098b42f4935c699ad9b9bce3dd1c/2-Figure1-1.png)
PDF] Mg2+-dependent conformational rearrangements of CRISPR-Cas12a R-loop complex are mandatory for complete double-stranded DNA cleavage | Semantic Scholar
![Probing CRISPR-Cas12a Nuclease Activity Using Double-Stranded DNA-Templated Fluorescent Substrates | Biochemistry Probing CRISPR-Cas12a Nuclease Activity Using Double-Stranded DNA-Templated Fluorescent Substrates | Biochemistry](https://pubs.acs.org/cms/10.1021/acs.biochem.0c00140/asset/images/large/bi0c00140_0007.jpeg)
Probing CRISPR-Cas12a Nuclease Activity Using Double-Stranded DNA-Templated Fluorescent Substrates | Biochemistry
![Mg2+-dependent conformational rearrangements of CRISPR-Cas12a R-loop complex are mandatory for complete double-stranded DNA cleavage | PNAS Mg2+-dependent conformational rearrangements of CRISPR-Cas12a R-loop complex are mandatory for complete double-stranded DNA cleavage | PNAS](https://www.pnas.org/cms/10.1073/pnas.2113747118/asset/086880a9-0d2e-441a-9961-1421d2c5fc45/assets/images/large/pnas.202113747fig03.jpg)
Mg2+-dependent conformational rearrangements of CRISPR-Cas12a R-loop complex are mandatory for complete double-stranded DNA cleavage | PNAS
![Enhancement of trans-cleavage activity of Cas12a with engineered crRNA enables amplified nucleic acid detection | Nature Communications Enhancement of trans-cleavage activity of Cas12a with engineered crRNA enables amplified nucleic acid detection | Nature Communications](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41467-020-18615-1/MediaObjects/41467_2020_18615_Fig1_HTML.png)
Enhancement of trans-cleavage activity of Cas12a with engineered crRNA enables amplified nucleic acid detection | Nature Communications
Kinetics Accelerated CRISPR-Cas12a Enabling Live-Cell Monitoring of Mn2+ Homeostasis | Analytical Chemistry
![Highly specific chimeric DNA-RNA-guided genome editing with enhanced CRISPR- Cas12a system: Molecular Therapy - Nucleic Acids Highly specific chimeric DNA-RNA-guided genome editing with enhanced CRISPR- Cas12a system: Molecular Therapy - Nucleic Acids](https://www.cell.com/cms/attachment/0a189998-d354-4163-9276-22a0a61e3ca8/fx1_lrg.jpg)
Highly specific chimeric DNA-RNA-guided genome editing with enhanced CRISPR- Cas12a system: Molecular Therapy - Nucleic Acids
![Cas12a target search and cleavage on force-stretched DNA - Physical Chemistry Chemical Physics (RSC Publishing) DOI:10.1039/D1CP03408A Cas12a target search and cleavage on force-stretched DNA - Physical Chemistry Chemical Physics (RSC Publishing) DOI:10.1039/D1CP03408A](https://pubs.rsc.org/image/article/2021/CP/d1cp03408a/d1cp03408a-f1_hi-res.gif)
Cas12a target search and cleavage on force-stretched DNA - Physical Chemistry Chemical Physics (RSC Publishing) DOI:10.1039/D1CP03408A
![An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing | Nature Communications An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing | Nature Communications](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41467-021-21996-6/MediaObjects/41467_2021_21996_Fig1_HTML.png)
An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing | Nature Communications
![The Off-Target Effect of CRISPR-Cas12a System toward Insertions and Deletions between Target DNA and crRNA Sequences | Analytical Chemistry The Off-Target Effect of CRISPR-Cas12a System toward Insertions and Deletions between Target DNA and crRNA Sequences | Analytical Chemistry](https://pubs.acs.org/cms/10.1021/acs.analchem.1c05499/asset/images/large/ac1c05499_0006.jpeg)
The Off-Target Effect of CRISPR-Cas12a System toward Insertions and Deletions between Target DNA and crRNA Sequences | Analytical Chemistry
Recognition of DNA Target Formulations by CRISPR-Cas12a Using a dsDNA Reporter | ACS Synthetic Biology
![Recognition of DNA Target Formulations by CRISPR-Cas12a Using a dsDNA Reporter | ACS Synthetic Biology Recognition of DNA Target Formulations by CRISPR-Cas12a Using a dsDNA Reporter | ACS Synthetic Biology](https://pubs.acs.org/cms/10.1021/acssynbio.1c00204/asset/images/large/sb1c00204_0008.jpeg)
Recognition of DNA Target Formulations by CRISPR-Cas12a Using a dsDNA Reporter | ACS Synthetic Biology
![CRISPR-Cas12a Possesses Unconventional DNase Activity that Can Be Inactivated by Synthetic Oligonucleotides: Molecular Therapy - Nucleic Acids CRISPR-Cas12a Possesses Unconventional DNase Activity that Can Be Inactivated by Synthetic Oligonucleotides: Molecular Therapy - Nucleic Acids](https://www.cell.com/cms/asset/562f998f-1305-46a3-8503-2538fe4aba95/gr1.jpg)